Chang Ge

Chang is in a collaborative program between the University of Toronto and Zhejiang University, co-supervised by Dr. Stephen Lye and Professor Jian Xu. During her postgraduate training, she has been actively engaged in both basic and translational research, with a particular focus on and trophoblast dysfunction at the maternal–fetal interface in underlying pregnancy complications such as preeclampsia and recurrent abortion.
Her Ph.D. research centers on the metabolic and epigenetic regulation of trophoblast function, with specific aims to elucidate how ACLY-mediated histone acetylation regulates trophoblast stem cell differentiation into syncytiotrophoblasts, to define disrupted signaling pathways and cell–cell interactions in preeclampsia, to establish real-time in vitro co-culture platforms modeling trophoblast invasion into the maternal decidua, and to investigate how trophoblast alterations drive immune cell dysregulation leading to maternal–fetal interface dysfunction.