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The Fruits of Our Labour

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2023 PUBLICATIONS

PROGESTERONE CONTROL OF MYOMETRIAL CONTRACTILITY

Shynlova O, Nadeem L, Lye S

DIFFERENTIATION OF PATIENT-SPECIFIC VOID URINE-DERIVED HUMAN INDUCED PLURIPOTENT STEM CELLS TO FIBRIBLASTS AND SKELETAL MUSCLE MYOCYTES

Kibschull M, Nguyen TTN, Chow T, Alarab M, Lye SJ, Rogers I

MYB AND ELF3 DIFFERENTIALLY MODULATE LABOR-INDUCCING GENE EXPRESSION IN MYOMETRIAL CELLS

Shchuka VM, Khader N, Dorogin A, Shynlova O, Mitchell JA

2022 PUBLICATIONS

THE EFFECT OF LOCAL ESTROGEN THERAPY ON THE URINARY MICROBIOME COMPOSITION OF POSTMENAPAUSAL WOMEN WITH AND WITHOUT RECURRENT URINARY TRACT INFECTIONS

Anglim BA, Phillips CD, Shynlova O, Alarab M

INTERNATIONAL UROGYNECOLOGICAL CONSULTATION (IUC): PATHOPHYSIOLOGY OF PELVIC ORGAN PROLAPSE (POP) 

Deprest JA, Cartwright R, Dietz HP, Brito LGO, Koch M, Allen-Brady K, Manonai J, Weintraub AY, Chua JWF, Cuffolo R, Sorrentino F, Cattani L, Decoene J, Page AS, Weeg N, Varella Pereira GM, Mori da Cunha de Carvalho MGMC, Mackova K, Hympanova LH, Moalli P, Shynlova O, Alperin M, Bortolini MAT

THE SELECTIVE PROGESTERONE RECEPTOR MODULATOR, PROMEGESTONE, DELAYS TERM PARTURITION AND PREVENTS SYSTEMIC INFLAMMATION-MEDIATED PRETERM BIRTH IN MICE

Shynlova O, Nadeem L, Dorogin A, Mesiano S, Lye S

AGE AND/OR POSTMENOPAUSAL STATUS AS RISK FACTORS FOR PELVIC ORGAN PROLAPSE DEVELOPMENT: SYSTEMATIC REVIEW WITH META-ANALYSIS

Brito LGO, Pereira GMV, Moalli P, Shynlova O, Manonai J, Weintraub AY, Deprest J, Bortolini MAT

FOUNDATIONAL SCIENCE AND MECHANISTIC INSIGHTS FOR A SHARED DISEASE MODEL: AN EXPERT CONSENSUS

Alperin M, Abramowitch S, Alarab M, Bortolini M, Brown B, Burnett LA, Connell KA, Damaser MS, de Vita R, Gargett CE, Guess MK, Guler Z, Jorge RN, Kelley RS, Kibschull M, Miller K, Moalli PA, Mysorekar IU, Routzong MR, Shynlova O, Swenson CW, Therriault MA, Northington GM

FOUNDATIONAL SCIENCE AND MECHANISTIC INSIGHTS FOR A SHARED DISEASE MODEL: AN EXPERT CONSENSUS: DEVELOPED BY THE AUGS BASIC SCIENCE SUBCOMMITTEE AND IUGA SPECIAL INTEREST GROUP

Alperin M, Abramowitch S, Alarab M, Bortolini M, Brown B, Burnett LA, Connell KA, Damaser M, de Vita R, Gargett CE, Guess MK, Guler Z, Jorge RN, Kelley RS, Kibschull M, Miller K, Moalli PA, Mysorekar IU, Routzong MR, Shynlova O, Swenson CW, Therriault MA, Northington GM

2021 PUBLICATIONS

A BROAD-SPECTRUM CHEMOKINE INHIBITOR BLOCKS INFLAMMATION-INDUCED MYOMETRIAL MYOCYTE-MACROPHAGE CROSSTALK AND MYOMETRIAL CONTRACTION

Boros-Rausch A, Shynlova O, Lye SJ

DECIDUAL INFLAMMATION DRIVES CHEMOKINE-MEDIATED IMMUNE INFILTRATION CONTRIBUTING TO TERM LABOR

Shynlova O, Boros-Rausch A, Farine T, Adams-Wardorf KM, Dunk C, Lye S

LANDSCAPE OF PRETERM BIRTH THERAPEUTICS AND A PATH FORWARD

Coler BS, Shynlova O, Boros-Rausch A, Lye S, McCartney S, Leimert KB, Xu W, Chemtob S, Olson D, Li M, Huebner E, Curtin A, Kachikis A, Savitsky L, Paul JW, Smith R, Adams Waldorf KM

PRO-INFLAMMATORY SIGNALS INDUCE 20α-HSD EXPRESSION IN MYOMETRIAL CELLS: A KEY MECHANISM FOR LOCAL PROGESTERONE WITHDRAWAL

Nadeem L, Balendran R, Dorogin A, Mesiano S, Shynlova O, Lye S

TRANSCRIPTIONAL CONTROL OF PARTURITION: INSIGHTS FROM GENE REGULATION STUDIES IN THE MYOMETRIUM

Khader N, Shchuka V, Shynlova O, Mitchell J

COMBINATION OF HISTOCHEMICAL ANALYSES AND MICRO-MRI REVEALS REGIONAL CHANGES OF THE MURINE CERVIX IN PREPARATION FOR LABOR

Chatterjee A, Saghain R, Dorogin A, Cahill L, Sled J, Lye S, Shynlova O

LLOW-INTENSITY PHYSICAL ACTIVITY MAY PROTECT PREGNANT WOMEN AGAINST SPONTANEOUS PRETERM LABOUR: A PROSPECTIVE CASE-CONTROL STUDY

Steckle V*, Shynlova O*, Lye S, Bocking A

2020 PUBLICATIONS

THE PREGNANT MYOMETRIUM IS EPIGENETICALLY ACTIVATED AT CONTRACILITY-DRIVING GENE LOCI PRIOR TO THE ONSET OF LABOR IN MICE

Shchuka V, Abatti L, Hou H, Dorogin A, Wilson M, Shynlova O, Mitchell J

MYOMETRIAL ACTIVATION: NOVEL CONCEPTS UNDERLYING LABOR

Shynlova O, Nadeem L, Zhang J, Dunk C, and Lye S

A BROAD SPECTRUM CHEMOKINE INHIBITOR PRESENTS PRETERM LABOR BUT NOT MICROBIAL INVASION OF THE AMNIOTIC CAVITY OR NEONATAL MORBIDITY IN A NONHUMAN PRIMATE MODEL

Coleman M, Orvis A, Wu T-Y, Dacanay M, Merillat S, Ogle J, Baldessari A, Kretzer N, Munson J, Boros-Rausch A, Shynlova O, Lye S, Rajagopal L, Adams Waldorf KM

2019 PUBLICATIONS

LOCAL ESTROGEN THERAPY MODULATES EXTRACELLULAR MATRIX AND IMMUNE RESPONSE IN THE VAGINAL TISSUE OF POST-MENOPAUSAL WOMEN WITH SEVERE PELVIC ORGAN PROLAPSE

Tyagi T, Alarab M, Leong Y, Lye S, Shynlova O

MicroRNA-TRANSCRIPTOME NETWORKS IN WHOLE BLOOD AND MONOCYTES OF WOMEN UNDERGOING PRETERM LABOUR

Paquette A, Shynlova O, Wu X, Kibschull M, Wang K, Price N, Lye S

PROBIOTIC LACTOBACILLUS RHAMNOSES GR-1 IS A UNIQUE PROPHYLACTIC AGENT THAT SUPPRESSES INFECTION-INDUCED MYOMETRIAL CELL RESPONSES

Kim B, Shynlova O, Lye S

TGFb1 SUPPRESSES THE ATIVATION OF DISTINCT dNK SUBPOPULATIONS IN PREECLAMPSIA

Zhang J, Dunk CE, Shynlova O, Caniggia I, Lye SJ

CYTOKINE CHANGES IN MATERNAL PERIPHERAL BLOOD CORRELATE WITH TIME-TO-DELIVERY IN PREGNANCIES COMPLICATED BY PREMATURE PRELABOR RUPTURE OF THE MEMBRANES

Ronzoni S, Steckle V, D'Souza R, Murphy KE, Lye S, Shynlova O

2018 PUBLICATIONS

LOCAL ESTROGEN THERAPY MODULATES EXTRACELLULAR MATRIX AND IMMUNE RESPONSE IN THE VAGINAL TISSUE OF POST-MENOPAUSAL WOMEN WITH SEVERE PELVIC ORGAN PROLAPSE

Tyagi T, Alarab M, Leong Y, Lye S, Shynlova O

MicroRNA-TRANSCRIPTOME NETWORKS IN WHOLE BLOOD AND MONOCYTES OF WOMEN UNDERGOING PRETERM LABOUR

Paquette A, Shynlova O, Wu X, Kibschull M, Wang K, Price N, Lye S

PROBIOTIC LACTOBACILLUS RHAMNOSES GR-1 IS A UNIQUE PROPHYLACTIC AGENT THAT SUPPRESSES INFECTION-INDUCED MYOMETRIAL CELL RESPONSES

Kim B, Shynlova O, Lye S

TGFb1 SUPPRESSES THE ATIVATION OF DISTINCT dNK SUBPOPULATIONS IN PREECLAMPSIA

Zhang J, Dunk CE, Shynlova O, Caniggia I, Lye SJ

CYTOKINE CHANGES IN MATERNAL PERIPHERAL BLOOD CORRELATE WITH TIME-TO-DELIVERY IN PREGNANCIES COMPLICATED BY PREMATURE PRELABOR RUPTURE OF THE MEMBRANES

Ronzoni S, Steckle V, D'Souza R, Murphy KE, Lye S, Shynlova O

2017 PUBLICATIONS

PERIHERAL MATERNAL LEUKOCYTES ARE ACTIVATED IN RESPONSE TO FACTORS SECRETED BY PREGNANT HUMAN UTERINE TISSUES

.   Farine T, Lye S. Shynlova O

PROGESTERONE VIA ITS TYPE-A RECEPTOR PROMOTES MYOMETRIAL GAP JUNCTION COUPLING

Nadeem L, Shynlova O, Mesiano S, Lye S

IMMUNOPHENOTYPING AND ACTIVATION STATUS OF MATERNAL PERIPHERAL BLOOD LEUKOCYTES DURING PREGNANCY AND LABOR, BOTH TERM AND PRETERM

Zhang J*, Shynlova O*, Sabra S, Bang A, Briollais L, Lye S

2016 PUBLICATIONS

COMPARATIVE CHARACTERIZATION OF VAGINAL CELLS DERIVED FROM PREMENOPAUSAL WOMEN WITH AND WITHOUT SEVERE PELVIC ORGAN PROLAPSE

Kufaishi H, Alarab M, Drutz H, Lye S. Shynlova O

STATIC MECHANICAL LOADING INFLUENCES THE EXPRESSION OF EXTRACELLULAR MATRIX AND CELL ADHESION PROTEINS IN VAGINAL CELLS DERIVED FROM PREMENOPAUSAL WOMEN WITH SEVERE PELVIC ORGAN PROLAPSE

Kufaishi H, Alarab M, Drutz H, Lye S. Shynlova O

MATRIX METALLOPROTEINASE EXPRESSION IN THE RAT MYOMETRIUM DURING PREGNANCY, TERM LABOUR, AND POSTPARTUM

Nguyen T, Shynlova O, Lye S

P-GLYCOPROTEIN EXPRESSION AND LOCALIZATION IN THE RAT UTERUS THROUGHT GESTATION AND LABOR

Shynlova O*, Huang QT*, Kibschull M, Zhong M, Yu YH, Matthews S, Lye S

MOLECULAR EVIDENCE OF FUNCTIONAL PROGESTERONE WITHDRAWAL IN HUMAN MYOMETRIUM

Nadeem L, Shynlova O, Matysiak-Zablocki E, Mesiano S, Dong X, Lye S

2015 PUBLICATIONS

ATTACHMENT OF PRIMARY VAGINAL FIBROBLASTS TO ABSORBABLE AND NON-ABSORBABLE IMPLANT MATERIALS COATED WITH PLATELET RICH PLASMA: POTENTIAL APPLICATION IN PELVIC ORGAN PROLAPSE SURGERY

Medel S, Alarab M, Kufaishi H, Drutz H, Shynlova O

STRETCH-INDUCED HUMAN MYOMETRIAL CYTOKINES ENHANCE IMMUNE CELL RECRUITMENT VIA ENDOTHELIAL ACTIVATION - THE MODEL OF PHYSIOLOGIC MYOMETRIAL INFLAMMATION

Lee Yu-H, Shynlova O, Lye S

HOXA13 REGULATES PHENOTYPE REGIONALIZATION OF HUMAN PREGNANT MYOMETRIUM

Liu L, Li H, Dargahi D, Shynlova O, Slater D, Jones SJ, Lye SJ, Dong X

2014 PUBLICATIONS

EXPRESSION OF EXTRACELLULAR MATRIX REMODELING PROTEINS IS ALTERED IN VAGINAL TISSUE OF PREMENOPOUSAL WOMEN WITH SEVERE PELVIC ORGAN PROLAPSE

Alarab M, Kufaishi H, Drutz H, Lye S, Shynlova O

INHABITATIONO OF INFECTION-INDUCED PRETERM BIRTH BY ADMINISTRATION OF BROAD SPECTRUM CHEMOKINE INHIBITOR IN MICE

Shynlova O, Dorogin A, Li Y, Lye S

A NEW ROLE FOR MONOCYTES IN MODULATING MYOMETRIAL INFLAMMATION DURING HUMAN LABOR

Srikhajon K*, Shynlova O*, Preechapornprasert A, Chanrachakul B, Lye S

2013 PUBLICATIONS

MYOMETRIAL IMMUNE CELLS CONTRIBUTE TO TERM PARTURITION, PRETERM LABOUR AND POST-PARTUM INVOLUTION IN MICE

Shynlova O, Nedd-Roderique T, Li Y, Dorogin A, Lye S

INFILTRATION OF MYELOID CELLS INTO DECIDUA IS A CRITICAL EARLY EVENT IN THE LABOUR CASCADE AND POST-PARTUM UTERINE REMODELING

Shynlova O, Nedd-Roderique T, Li Y, Dorogin A , Nguyen T , Lye S

GENES RESPONSIBLE FOR VAGINAL EXTRACELLULAR MATRIX METABOLISM ARE MODULATED BY WOMEN'S REPRODUCTIVE CYCLE AND MENOPAUSE

Shynlova O, Bortolini MA, larab M

PHYSIOLOGIC UTERINE INFLAMMATION AND LABOUR ONSET: INTEGRATION OF ENDOCRINE AND MECHANICAL SIGNALS

Shynlova O, Lee YH, Srikhajon K, Lye S

PROLIFERATIVE ACTION OF THE ANDROGEN RECEPTOR IN HUMAN UTERINE MYOMETRIAL CELLS - A KEY REGULATOR FOR MYOMETRIUM PHENOTYPE PROGRAMMING

Liu L, Li Y, Xie N, Shynlova O, Challis JR, Slater D, Lye S, Dong X

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